To defeat the Giant Buzz Blob, Link must sprinkle Magic Powder upon it. Then, he must strike it with the Sword. Throughout the battle, Giant Buzz Blob will shoot lightning bolts which the young hero must avoid. When first encountering it, Giant Buzz Blob will gloat that it's not a weakling and that Link's sword is no match for it.
In Link's Awakening for Nintendo Switch, the Giant Buzz Blob is redesigned to be colored green in its Buzz Blob state, although it is still colored blue in its weakened state.